foreign body reaction mimicking intracranial abscess following the use of oxidized regenerated cellulose (surgiceltm): case report and literature review

Background & importance: the use of local hemostatic agents in neurosurgery is mandatory in order to control the sequelae of intracerebal hemorrhage. it is widely used in oxidized regenerated cellulose (surgicel™). case presentation: a 54-year-old man previously operated for grade ii meningioma came back to our attention due to the onset of left side arm weakness one month after surgery. the ct scan and mri showed an extensive lesion on the surgical site with the suspect of intracranial abscess. intraoperative detections suggested the features of a granulomatous foreign body reaction. conclusion: the occurrence of granulomatous reaction to oxidized regenerated cellulose, when used as hemostatic agent, is a very rare finding following intracranial surgery.