effect of eightweeks of resistance training with spirulina platensis ingestion on the heartweight and cardiac c/ebpβ expression in male rats

Background: resistance training and spirulina consumption could change the expression of the gene involved in hypertrophy. objectives: the study investigated the effect of eight weeks of resistance training with spirulina platensis ingestion on the heart weight and cardiac ccaat-enhancer-binding proteins beta (c/ebpβ) expression in male rats. methods: we divided 32 male sprague dally rats into four groups: control (co; n = 8), spirulina platensis (sp; n = 8), resistance training (re; n = 8), and spirulina plus resistance training (sp + re; n = 8). the resistance training group practiced five sessions a week for eight weeks. spirulina 200 mg/kg/day was used in the supplement group and the exercise plus spirulina platensis group. twenty-four hours after the last training session, the gene expression was measured using real-time pcr. results: the results showed that resistance training significantly increased heart weight (p = 0.001) and left ventricular weight (p = 0.001) but significantly decreased cebp (p = 0.001). spirulina insignificantly increased heart weight (p = 0.46), significantly increased left ventricular weight (p = 0.001), and significantly decreased cebp (p = 0.02). on the other hand, resistance training plus spirulina significantly increased heart weight (p = 0.001) and left ventricular weight (p = 0.001) but had no significant effect on c/ebpβ reduction (p = 0.10). conclusions: a combination of resistance training and spirulina supplementation cannot have a significant effect on the important signaling factor in heart hypertrophy.