antiapoptotic effects of continuous training and selenium consumption on the liver tissue of cadmium-exposed rats

Background: cadmium has negative effects on various tissues of the body while selenium has antioxidant activities. moreover, the benefits of exercise training for apoptotic factors including caspase-3 and cytochrome c, as well as cyclin d, have been regarded. objectives: therefore, the present studyaimedto evaluate the anti-apoptotic effects of continuous trainingandseleniumconsumption on the liver tissue of cadmium-exposed rats. methods: in this study, 25 rats were selected and randomly divided into five groups of five rats including: (1) control, (2) selenium consumption, (3) continuous training, (4) continuous training with selenium consumption, and (5) sham. for eight weeks, groups 1 to 4 received peritoneal cadmium (2 mg/kg) daily; groups 2 and 4 received peritoneal selenium (0.23 mg/kg) daily; and groups 3 and 4 performed continuous training three sessions per week. caspase-3, cytochrome c, and cyclin d were measured at the protein level. results: cadmium consumption significantly increased the protein levels of caspase-3 and cytochrome c and decreased cyclin d in rats (p = 0.001). selenium consumption and continuous training significantly decreased the protein levels of caspase-3 and cytochrome c and increased cyclin d in rats exposed to cadmium (p = 0.001). continuous training along with selenium consumption had interactive effects on increasing the protein levels of cyclin d in rats exposed to cadmium (p = 0.02). conclusions: it appears that continuous training and selenium consumption have interactive anti-apoptotic effects in the liver tissue of cadmium-exposed rats.