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   Exploring Transcriptional Relationships Implicated in Autism and Inflammatory Bowel Diseases Using Systems Biology Approaches  
   
نویسنده izadi fereshteh ,soheilifar mohammad hasan ,keshmiri neghab hoda ,soheilifar mahya ,amini razieh
منبع journal of applied biotechnology reports - 2021 - دوره : 8 - شماره : 2 - صفحه:180 -185
چکیده    Introduction: understanding the association among various disorders has remarkably improved their diagnosis and therapies. it has been observed that autism and inflammatory bowel diseases (ibds) cause a sort of inflammation. exploring the relationship between them will lead to discovering important involved genes and in turn will eventually help discover any possible common therapeutic protocols. the aim of the present study was to determine the correlation of autism spectrum disorders (asds) and ibds.materials and methods: the common genes associated with autism spectrum disorders and ibds were retrieved from disgenet. sfari and trrust databases were subjected to an in-silico data analysis framework to explore predictive genes and the related pathways.results: eleven genes including hla-drb1, mthfr, pon1, il6, mtor, setd2, gstm1, apc, ifng, serpine1 and mapk1 regulated by yy1 and irf1 transcription factors were characterized as discriminating molecules which by further screening were enriched in pathways mostly involved in neutrophil apoptosis, neutrophil homeostasis, chemokine biosynthesis and the regulation of immune system response.conclusions: according to findings it can be stated that the identified common genes were associated with a wide range of pathogenic mechanisms.
کلیدواژه Autism Spectrum Disorders ,Inflammatory Bowel Diseases ,Disease-associated Genes ,Network Analysis
آدرس university of southampton, academic unit of cancer science, cancer research uk center, faculty of medicine, southampton general hospital, UK, academic center for education, culture and research (acecr), medical laser research center, yara institute, department of medical laser, iran, academic center for education, culture and research (acecr), medical laser research center, yara institute, department of photo healing and regeneration, iran, malayer university, faculty of sciences, department of biology, Iran, hamadan university of medical sciences, research center for molecular medicine, school of medicine, iran
 
     
   
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