The Association Between Matrix Metalloproteinases-9–1562 C/T Polymorphism and Lung Cancer Susceptibility: A Systematic Review and Meta-Analysis

Introduction: matrix metalloproteinases (mmps) are a family of zinc dependent proteinase. several studies have reported the association between the single nucleotide polymorphisms(c/t) -1562 in the mmp-9 promoter and the risk of cancer. in this study we decided to carry out a comprehensive meta-analysis to obtain a reasonable result about the association between this polymorphism and the risk of lung cancer. materials and methods: a complete literature review was conducted within the databases of isi web of knowledge, google scholar and pubmed for studies on lung cancer published from 2002 to 2018. a meta-analysis was conducted which included more than 3000 case and control subjects. the pooled odds ratio (or) and 95% confidence intervals (ci) were used for dominant, recessive and co-dominant mmp-9 genotypes to assess the strength of the association. results: analysis indicated no significant association between mmp-9-1562c/t polymorphism and the risk of lung cancer, dominant model; [ct+tt/cc]: or=0.972, 95% ci=0.811–1.164, recessive model [cc+ct/tt] or= 1.027, 95% ci=0.651–1.618 and co-dominant model [tt/ cc] or=0.983, 95% ci=0.550–1.755. conclusions: no association was observed between the mmp9-1562 c/t polymorphism and the incidence of lung cancer. meta-analysis demonstrated that this polymorphism can’t serve as a diagnostic marker for lung cancer.