Association Between Plasma Lipids Profile and Lipids Oxidizability in Healthy Men

Introduction: the aim of the present study was to determine the susceptibility of lipids to cu-induced peroxidation in diluted plasma and its relation with plasma lipids and lipoproteins in a group of healthy men. materials and methods: in 100 healthy men volunteers (age range 20-55 years with a mean of 36.8±10.3 years), fasting plasma levels of lipoprotein (a) [lp (a)], total cholesterol (tc), high-density lipoprotein-cholesterol (hdl-c), low-density lipoprotein-cholesterol (ldl-c), and triglycerides (tg) were assayed. the cu2+-induced lipid peroxidation was evaluated. lipid oxidation was estimated by monitoring the change of conjugated dienes in the diluted plasma following the addition of cu2+. the kinetic curves of the accumulation of lipid peroxide products were prepared, and a number of quantitative parameters including lag time, time of maximal oxidation rate (t-max), and maximal accumulation of absorbing products (od-max) were evaluated. results: the tg concentrations were positively correlated with lag time and t-max (r=0.33, p < 0.01 and r=0.24, p < 0.05) respectively. also, tc and ldl-c were positively correlated with od-max (r=0.28, p < 0.01 and r=0.26, p < 0.05 respectively), and hdl-c was negatively correlated (r=-0.23, p < 0.05) with t-max. no significant correlation was observed between other variables and lipid oxidizability parameters. conclusions: results of this research indicate that tg increased the resistance of ldl and vldl against initiation of lipid oxidation. in addition, hdl-c induced the susceptibility of lipid oxidizability.