Effects of Ginger on Advanced Glycation End-Products and Inflammation in the Ovarian Tissue of Streptozotocin-Induced Diabetic Rats

Background and aim: advanced glycation end products (ages) and inflammation play a crucial role in the progression of diabetic complications, including ovarian disorders. the current research investigated the potential impact of hydroalcoholic extract of ginger (zingiber officinale) on hyperglycemia-induced ages and inflammatory markers. methods: a total of 96 female wistar rats were randomized into four groups (n=24 in each group) as follows: 1) control, 2) diabetes, 3) diabetes + 200 mg/kg ginger, 4) diabetes + 400 mg/kg ginger. streptozotocin (stz) - induced diabetic rats, as our experimental model for diabetes, orally received 200 or 400 mg/kg/day ginger extract for eight weeks. at the end of the treatment period, body weight, ovarian weight, serum ages level, ovarian rage, il-1β, and tnf-α mrna levels were measured.results: at the end of the study, diabetic rats exhibited an obvious decrease in body weight (p < 0.01) and ovarian weight (p < 0.01) compared to normal rats. however, ginger supplementation (200 mg/kg) exhibited a significant increment in ovarian weight (p < 0.05) and body weight (p < 0.01). these changes were also more pronounced in the diabetic rats treated with 400 mg/kg ginger extract (p < 0.01). serum ages (p < 0.001) and ovarian rage (p < 0.01), il-1β (p < 0.01), and tnf-α (p < 0.01) mrna levels were significantly elevated in diabetic rats compared with control group. administration of the diabetic group with 200 mg/kg ginger extract significantly ameliorated the serum level of ages (p < 0.01) and the transcript levels of rage (p < 0.05), tnf-α (p < 0.01) and il-1β (p < 0.05). the 400 mg/kg ginger extract dose remarkably alleviated ages (p < 0.001) in the serum and rage (p < 0.01), tnf-α (p < 0.01), and il-1β (p < 0.01) in the ovary of diabetic rats.conclusion: the present study's findings revealed that daily administration of ginger extract reduces ages and the transcript levels of rage and inflammatory markers in the stz- induced female rats.