clinicopathological characteristics of gastric cancer in iranian patients referred to imam reza hospital during 2008 to 2017

Background and aim: there are a limited number of studies regarding the clinicopathological features of gastric cancer. here, the clinicopathological features of gastric cancer including tumor type and size, degree of differentiation, tumor operability, and immunohistochemically results of e-cadherin and p53 expression was investigated in iranian patients. methods: this retrospective study was performed on patients who were admitted at imam reza hospital in tehran-iran from 2008 to 2017 with a diagnosis of gastric cancer. required information including age, sex, type of cancer, pathology, and immunohistochemistry (ihc) results and treatment were extracted from the hospital archive. results: out of 264 enrolled patients (with the mean age of 70.03±14.01 years), 180 cases were men. the frequency of intestinal-type, diffuse-type, lymphoma and gist tumor were 54.5%, 27.7%, 12.25% and 5.92% respectively. in addition, 67.58% and 13.83% of the tumors were undifferentiated and poorly differentiated respectively. surgery was less probable in less differentiated tumors (r=0.582 p=0.001). the surgery rate in gist, intestinal- type, and diffuse-type tumors were 100%, 57%, and 14.4%, respectively. ihc results showed that e- cadherin expression was present in 78.6, of which 50.9% were weakly positive (+1). also, the high expression of p53 was observed in 60.7% of patients. conclusion: according to the data, we can conclude that poorly differentiated tumors, decreased expression of e-cadherin, and increased expression of p53 is linked to poor prognosis in iranian patients with gastric cancer. in this regard, further clinical trials and multicenter studies should be done to evaluate the possible factors for improving the prognosis and survival rates of iranian patients with gastric cancer.