effect of acid-base balance on cytokines serum levels and short-term outcomes in kidney transplant recipients; a randomized clinical trial

Background: control of blood acids and bases can help prevent many potentially life-threatening disorders in end stage renal disease (esrd) patients. aim of this study was to assess the effect of acid-base balance on cytokines serum levels and short-term outcomes in kidney transplant recipients. materials and methods: in this randomized clinical trial study, 40 patients with end-stage renal disease aged 18 to 70 who had undergone a kidney transplant from a living donor in modarres hospital during 2016-2017 were included. the primary outcomes measured in this study were sera levels of cytokine such as il-2, il-10, ifn-γ and bun and cr serum after the treatment of acidosis in kidney transplant recipients. results: mean±sd of the patient’s age was 42±12.6 years. results showed that there is a significant difference in means of il-2, il-10, and ifn-γ between the intervention and control groups over the time (for all p<0.05). we also found that correction of acidosis occurred with reduces of ifn-γ to -1.74 in the intervention group compared to the group receiving saline (p=0.011); and reduction for il-2 was -1.37 (p=0.025). the concentration of anti-inflammatory cytokine of il-10 was increased to 2.85 (p<0.001). conclusion: the results clearly suggest that correction of acidosis in renal transplant patients during surgery helps improve the performance of allograft in the short run; however, more studies are recommended, taking into account the long-term and short-term effects of this intervention.