coagulation factor xiii-a a614t gene variation is suggestive of founder effect in iranian patients with sever congenital factor xiii deficiency

Factor xiii (fxiii) is a heterotetramer consisting of two subunits, fxiii-a and fxiii-b. several common gene variations were observed in fxiii-a gene with obvious ethnic difference. this study assessed prevalence of a614t as a common fxiii-a gene variation among iranian patients with fxiii deficiency (fxiiid). materials and methods: this study was conducted on eighty iranian unrelated individuals with fxiiid. genotype analysis for fxiii-a a614t gene variation was performed for all individuals. results: molecular analysis of these iranian populations revealed that all studied patients were homozygous for t allele at codon 204 of fxiii-a1 subunit. conclusion: present of t allele at codon 204 of fxiii-a1 subunit among all study population can be suggestive of founder effect.