the effect of adding aprepitant to ondansetron on postoperative nausea and vomiting after laparoscopic cholecystectomy: a randomized controlled trial

Background: postoperative nausea and vomiting (ponv) present a significant challenge for physicians and patients. the ponv in cholecystectomy, particularly laparoscopic cholecystectomy (lc), has a high prevalence. ondansetron is the first-line drug to prevent ponv. recently, aprepitant has been introduced as a new drug to prevent ponv. objectives: the aim of this study was to investigate the effect of adding aprepitant to ondansetron on preventing ponv after lc. methods: this randomized controlled trial was conducted on 60 patients who were candidates for lc. one hour before the operation, groups a and b received placebo and aprepitant, respectively. then, both groups were administered ondansetron at the same time as the operation. finally, patients were assessed for ponv at 6 and 24 hours after lc based on the likert scale. results: there was no significant difference in the duration of anesthesia and operation between the two groups. the results of the study demonstrated that at 6 and 24 hours after lc, the severity of ponv in the study group was significantly lower (p < 0.0001). in addition, the length of hospitalization (loh) was not significantly different between the two groups (p = 0.71). also, the basic variables did not have a significant effect on the severity of ponv. conclusions: the results of the study showed that adding aprepitant to ondansetron can significantly reduce ponv in lc compared to the control group.