Assessment of the Effect of Granisetron on the Gastric Cross-Sectional Area By Ultrasound on Patients Undergoing Elective Cesarean Section: A Randomized Double-Blind Study

Background: gastric ultrasound is considered a valuable tool for the assessment of gastric volume preoperatively.materials and methods: the goal of this study was to assess the effect of granisetron on the gastric cross-sectional area by ultrasound estimation of its cross-sectional area for elective cesarean section. sixty patients were assigned randomly into one of 2 groups; granisetron group (n=30): received 1 mg granisetron diluted in 10 ml normal saline 0.9%. control (n=30): received 10 ml of normal saline 0.9%. cross-sectional area and volume of stomach contents were measured using ultrasound immediately before administration of the study drug and one hour later.results: no statistical difference was detected in post-treatment antral csa nor gastric residual volume between the two groups (4.8±1.4 vs 4.6±2.1, p: 0.8) and (50±19 vs 57±27, p: 0.3) for antral csa and gastric volume comparison between both groups. however, a significant statistical difference was found in antral csa pre and post-granisetron administration (4.8±1.4 vs 4 ±1.2; p<0.001). the granesitron group had a statistically significantly lower rate of nausea and vomiting than the control group.conclusion: based on ultrasonographic measurement granesitron could effectively reduce the gastric cross-sectional area when administered preoperatively to parturients undergoing elective cs.