Effects of Anesthetic Management on Inflammatory Markers in Patients After Major Abdominal Surgeries: A Double-Blind Controlled Study

Background: surgical trauma induces systemic inflammatory responses. we aimed to evaluate the influence of different analgesic models on postoperative pain and inflammatory markers modulation after major abdominal surgeries.materials and methods: a total of 105 patients scheduled for elective abdominal colorectal surgeries were selected and randomly assigned to one of the three groups: group-1 (gm) four micrograms/kg of it morphine; group-2 (gml) four microgram/kg of it morphine plus 1.5 mg/kg intravenous lidocaine loading dose and 2 mg/min saline infusion during the operation and the next 4 hours postoperative; group-3 (g0, control group) no added drugs.results: pain scored statistically significant lower figures in gml than the other two groups; p<0.001. tumor necrosis factor-alpha serum levels showed a statistically significant difference between the three groups; p <0.001; gml showed the lowest level, followed by group gm and group 0 (10.3±4.4 vs. 20±4.4 vs. 26±7.5). transforming growth factor beta-1 demonstrated the highest levels measured in gml, high levels in gm, and the lowest level in g0; p<0.001, where mean serum levels were 43.1±12.5, 26 ±4.2, and 18.9±7.7, respectively. opioid consumption was significantly lower in gml than other two groups; p<0.001.conclusion: intraoperative and early postoperative intravenous lidocaine infusion significantly improved the quality of postoperative analgesia. optimizing analgesia in anesthetic management has a favorable effect on the pro and anti-inflammatory mediators.