Preventive Effects of NSAIDs on Lung Tissue Oxidative Damage in an Animal Sepsis Model

Background: sepsis is a heterogeneous syndrome caused by a dysregulated host response to infection. inflammatory cascades have a critical role in sepsis and can potentially be suppressed by anti-inflammatory compounds. therefore, this study was focused on the antiseptic effects of non-steroidal anti-inflammatory drugs (nsaids) on lung injuries based on cecal ligation and puncture (clp) surgery.materials and methods: male wistar rats were divided into 6 groups (n=60) as follows: control, laparotomy (lap), clp, and three treatment groups including indomethacin, celecoxib, and aspirin (2 mg/kg b.w) taken orally every 12 hours for 2 days. the rats were sacrificed after 48 hours, and the lung tissue was subjected to determine lipid peroxidation (lp), myeloperoxidase (mpo), glutathione enzyme (gsh)) and inflammatory genes expression (cyclooxygenase-2 (cox-2), cd177, and mpo).results: cecal ligation and puncture caused lung injury by changes in antioxidant enzymes and genes expression (p<0.05). treatments with indomethacin, celecoxib, and aspirin as anti-inflammatory compounds significantly improved antioxidant enzymes by reducing lp and mpo levels and genes expression and increasing the level of gsh (p<0.05).conclusion: sepsis caused oxidative damage in the lung tissue, and nsaids effectively prevented and improved these injuries.