Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial

Background: we aimed to investigate the efficacy of high-dose vitamin c, melatonin, and zinc in patients with severe covid-19.materials and methods: twenty-one adult patients were randomized 1:1 to standard care alone or standard care plus iv vitamin c (2 g, q6hr), oral melatonin (6 mg, q6hr), and oral zinc sulfate (50 mg, q6hr) for 10 days. patients were monitored for changes in hypoxemia and inflammatory markers.results: both treatment modalities were effective to improve pao2/fio2 and oxygen saturation. however, there were no significant differences between the 2 study groups (p>0.05). there were reductions in crp, esr, and ldh levels in both study groups, although were not significant. no significant difference was noted in the length of icu stay between the 2 study groups (p=0.3).conclusion: our study suggests that the addition of vitamin c, melatonin, and zinc to standard care is not associated with considerable improvement in patients with severe covid-19.