Spontaneous Pneumomediastinum Unrelated to Invasive Ventilation in a Patient with SARS-CoV-2 (COVID-19): A Case Report

Spontaneous pneumomediastinum (sp) is a rare complication that has not been reported in patients with coronavirus disease 2019 (covid-19). in this report, we introduce a patient with covid-19 with sp unrelated to aggressive ventilation. a 39-year-old woman with covid-19 with ards sign was admitted to the intensive care unit (icu) of babol rouhani hospital. she died four days after hospitalization with pneumomediastinum with subcutaneous emphysema. according to a chest x-ray and ct scan, the patient had sp before admission and aggressive ventilation. spontaneous pneumomediastinum could be a complication of acute respiratory syndrome in covid-19 infected patients with unclear pathogenesis.