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Autophagy Role as a Double-Edged Sword in Anesthesiology and Critical Care
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نویسنده
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zandi milad ,fazeli maryam ,ghadimi parnian ,soltani saber ,azizi jalilian farid ,banai shahani aryan ,behboudi emad ,pourhossein behzad
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منبع
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journal of cellular and molecular anesthesia - 2021 - دوره : 6 - شماره : 1 - صفحه:39 -49
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چکیده
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Autophagy is a conserved lysosomal degradation pathway that breaks down cytoplasmic components and is essential for host cellular immune response. the activity of autophagy at a basic rate is crucial for homeostasis. autophagy has emerged in recent years as a major mechanism in many neurodegenerative diseases. the regulation of microbial infections and inflammatory responses can be significantly influenced by autophagic modulators. in this study, we explain the autophagy role as a double-edged sword in anesthesiology and critical care. future studies should focus on investigating the molecular mechanism of interplay between pathogen-host-autophagy and on studying whether autophagy inducers/inhibitors can exert suitable modulatory immunomodulatory effects. potential organ protection through autophagy pathways might be an advantage in patients undergoing anesthesia and/or needing critical care.
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کلیدواژه
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Autophagy ,Anesthesiology ,Viral Infections
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آدرس
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tehran university of medical sciences, school of public health, department of virology, Iran, hamadan university of medical sciences, faculty of medicine, department of medical virology, Iran, guilan university of medical sciences, faculty of medicine, Iran, tehran university of medical sciences, school of public health, department of virology, Iran, hamadan university of medical sciences, faculty of medicine, department of medical virology, Iran, tehran university of medical sciences, students’ scientific research center, Iran, golestan university of medical sciences, faculty of medicine, department of microbiology, Iran, hamadan university of medical sciences, faculty of medicine, department of medical virology, Iran
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Authors
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