Evaluation of relative efficacy of hypertonic saline and lactated ringer's solutions in experimentally-induced Hypo-volumic shock in dogs

This study was conducted to evaluate the relative efficacy of bolus administration of lactated ringer's (lrs) and hypertonic saline (hss) solutions at the same dose rate in hypovolaemic shock (hs). twelve healthy adult mongrel dogs were acclimatized and baseline data were obtained. the animals were then subjected to hs through shedding blood and mean arterial pressure (map) of < 40 mm of hg was considered as cut-off point for the development of hs. after 30 minutes of hs,the dogs were randomly divided into two equal groups (a & b) before initiation of treatment. the dogs of group a were infused with lrs @ 4 mlkg-1 body weight (bw) followed by slow administration of lrs @ 10 ml kg-1 bw,while animals of group b were administered with hss @ 4 ml kg-1 bw followed by slow administration of normal saline @ 10 ml kg-1 bw. relative efficacy was measured through map,haematological parameters,serum electrolytes and blood ph. all parameters were measured during shock,and 30,60 minutes,3,6,12,and 24 hours of post-infusion. the animals of group b showed better recovery from shock,while 50% mortality was observed in the group a animals at the monitoring time. in group b,the mean ±sd of map was 116±8.0,equivalent to baseline within 60 minutes of infusion but in group a,it was far less than the baseline value. sodium elevated above baseline in the group b animals but within observing time it became close to the baseline. blood ph was restored towards normal more rapidly in group b animals which was significantly different from the group a animals (p < 0.05). recovery towards normal baseline values of measured variables was more rapid and sustained for the hss treated group. it was concluded that hss has a rapid effect in resuscitating the dogs from hs than lrs. © pakistan academy of sciences.