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Molecular characterization of the onset and progression of colitis in inoculated interleukin-10 gene-deficient mice: A role for PPAR α
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نویسنده
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knoch b. ,barnett m.p.g. ,cooney j. ,mcnabb w.c. ,barraclough d. ,laing w. ,zhu s. ,park z.a. ,maclean p. ,knowles s.o. ,roy n.c.
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منبع
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ppar research - 2010 - شماره : 0
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چکیده
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The interleukin-10 gene-deficient (il 10 -/-) mouse is a model of human inflammatory bowel disease and ppara has been identified as one of the key genes involved in regulation of colitis in the bacterially inoculated il 10 -/- model. the aims were to (1) characterize colitis onset and progression using a histopathological,transcriptomic,and proteomic approach and (2) investigate links between ppar and il10 using gene network analysis. bacterial inoculation resulted in severe colitis in il 10 -/- mice from 10 to 12 weeks of age. innate and adaptive immune responses showed differences in gene expression relating to colitis severity. actin cytoskeleton dynamics,innate immunity,and apoptosis-linked gene and protein expression data suggested a delayed remodeling process in 12-week-old il 10 -/- mice. gene expression changes in 12-week-old il 10 -/- mice were related to ppar signaling likely to control colitis,but how ppar activation might regulate intestinal il10 production remains to be determined. copyright © 2010 bianca knoch et al.
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آدرس
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food,metabolism and microbiology section,food and textiles group,agresearch grasslands,tennent drive,palmerston north 4442,new zealand,institute of food,nutrition and human health massey university,tennent drive, New Zealand, food,metabolism and microbiology section,food and textiles group,agresearch grasslands,tennent drive, New Zealand, plant and food research east street,hamilton 3214 and 120 mt albert road,sandringham, New Zealand, food and textiles group,agresearch grasslands,tennent drive,palmerston north 4442,new zealand,riddet institute,massey university, New Zealand, plant and food research east street,hamilton 3214 and 120 mt albert road,sandringham, New Zealand, plant and food research east street,hamilton 3214 and 120 mt albert road,sandringham, New Zealand, faculty of medical and health sciences,university of auckland,85 park road,grafton, New Zealand, bioinformatics,mathematics and statistics section,agresearch grasslands,tennent drive, New Zealand, bioinformatics,mathematics and statistics section,agresearch grasslands,tennent drive, New Zealand, food,metabolism and microbiology section,food and textiles group,agresearch grasslands,tennent drive, New Zealand, food,metabolism and microbiology section,food and textiles group,agresearch grasslands,tennent drive, New Zealand
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Authors
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