Role of PPARα in hepatic carbohydrate metabolism

Tight control of storage and synthesis of glucose during nutritional transitions is essential to maintain blood glucose levels,a process in which the liver has a central role. pparα is the master regulator of lipid metabolism during fasting,but evidence is emerging for a role of pparα in balancing glucose homeostasis as well. by using pparα ligands and pparα-/- mice,several crucial genes were shown to be regulated by pparα in a direct or indirect way. we here review recent evidence that pparα contributes to the adaptation of hepatic carbohydrate metabolism during the fed-to-fasted or fasted-to-fed transition in rodents. copyright © 2010 annelies peeters and myriam baes.