WY-14643,a potent peroxisome proliferator activator receptor-α PPAR-α agonist ameliorates the inflammatory process associated to experimental periodontitis

We have investigated the effects of wy14643,a potent peroxisome proliferator activator receptor- (ppar- ) agonist,in a rat model of ligature-induced periodontitis. male sprague-dawley rats were lightly anaesthetized with pentobarbitone (35mg/kg). sterile,2-0 black braided silk thread was placed around the cervix of the lower left first molar and knotted medially. animals received wy14643 (1mg/kg i.p,daily for eight days). eighths days after placement of the ligature,we evaluated several markers of inflammation such us (1) myeloperoxidase activity,(2) a cytokines and adhesion molecules expression,(3) nf-κb expression,(4) inos expression,(5) the nitration of tyrosine residues,(6) activation of the nuclear enzyme poly(adp-ribose) polymerase,(7) apoptosis,and (8) the degree of gingivomucosal tissues injury. administration of wy14643 significantly decreased all of the parameters of inflammation as described above. these results demonstrate that wy14643 exerts an anti-inflammatory role during experimental periodontitis and is able to ameliorate the tissue damage. © 2010 enrico briguglio et al.