Changes in the 24h rhythmicity of liver PPARs and peroxisomal markers when feeding is restricted to two daytime hours

Restricted feeding (rf) during daytime is associated with anticipatory activity before feeding,marked hyperphagia after mealtime,adjustments in hepatic metabolism,and the expression of a food-entrained oscillator (feo). 24h rhythmicity of liver ppar,and,peroxisomal markers (pmp70,aox,and catalase),and free fatty acids (ffas) during rf was evaluated. the effect of fasting-refeeding was also studied. results showed (1) higher levels of ffa before feeding,(2) a shift of ppar and ppar before and of ppar peaks after feeding,(3) an increase in peroxisomal markers,(4) a shift of pmp70 and aox peaks before feeding,and of maximal catalase activity in the dark period,(5) changes in the fasting-refeeding response,and (6) high correlations (0.9) of serum corticosterone with ppar and ppar and of pmp70 with ppar. in conclusion,24h rhythmicity of ffa,liver ppars,and peroxisomal markers are biochemical adaptations associated with daytime rf and feo expression. copyright 2011 julieta b. rivera-zavala et al.