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Skeletal effects of the saturated 3-thia fatty acid tetradecylthioacetic acid in rats
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نویسنده
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stunes a.k. ,westbroek i. ,fossmark r. ,berge r.k. ,reseland j.e. ,syversen u.
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منبع
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ppar research - 2011 - شماره : 0
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چکیده
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This study explores the skeletal effects of the peroxisome proliferator activated receptor (ppar)pan agonist tetradecylthioacetic acid (tta). rats,without (study i) and with ovariectomy (ovx) or sham operation (study ii),were given tta or vehicle daily for 4 months. bone markers in plasma,whole body and femoral bone mineral density and content (bmd and bmc),and body composition were examined. histomorphometric and biomechanical analyses (study i) and biomechanical and ct analyses (study ii) of the femur were performed. normal rats fed tta had higher femoral bmd and increased total and cortical area in femur compared to controls. the ovariectomized groups had decreased bmd and impaired microarchitecture parameters compared to sham. however,the tta ovx group maintained femoral bmc,trabecular thickness in the femoral head,and cortical volume in the femoral metaphysis as sham. tta might increase bmd and exert a light preventive effect on estrogen-related bone loss in rats. copyright © 2011 astrid kamilla stunes et al.
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آدرس
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department of cancer research and molecular medicine,faculty of medicine,mtfs norwegian university of science and technology,olav kyrres gate 9, Norway, departments of orthopedics and internal medicine,erasmus university,3000 dr, Netherlands, department of cancer research and molecular medicine,faculty of medicine,mtfs norwegian university of science and technology,olav kyrres gate 9,7489 trondheim,norway,department of gastroenterology and hepatology,st. olav's university hospital, Norway, department of medicine,university of bergen,5020 bergen,norway,department of heart diseases,haukeland university hospital, Norway, department of biomaterials,institute for clinical dentistry,university of oslo, Norway, department of cancer research and molecular medicine,faculty of medicine,mtfs norwegian university of science and technology,olav kyrres gate 9,7489 trondheim,norway,department of endocrinology,st. olav's university hospital, Norway
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Authors
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