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The current knowledge of the role of PPAR in hepatic ischemia-reperfusion injury
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نویسنده
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elias-miró m. ,jiménez-castro m.b. ,mendes-braz m. ,casillas-ramírez a. ,peralta c.
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منبع
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ppar research - 2012 - شماره : 0
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چکیده
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Strategies to improve the viability of steatotic livers could reduce the risk of dysfunction after surgery and increase the number of organs suitable for transplantation. peroxisome proliferator-activated receptors (ppars) are major regulators of lipid metabolism and inflammation. in this paper,we review the ppar signaling pathways and present some of their lesser-known functions in liver regeneration. potential therapies based on ppar regulation will be discussed. the data suggest that further investigations are required to elucidate whether ppar could be a potential therapeutic target in liver surgery and to determine the most effective therapies that selectively regulate ppar with minor side effects. copyright © 2012 m. elias-miró et al.
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آدرس
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institut d'investigacions biomèdiques august pi i sunyer (idibaps),esther koplowitz center,roselló 149-153, Spain, institut d'investigacions biomèdiques august pi i sunyer (idibaps),esther koplowitz center,roselló 149-153, Spain, departamento de patologia e medicina legal,faculdade de medicina,universidade de sao paulo,14049-900 sao paulo, Brazil, institut d'investigacions biomèdiques august pi i sunyer (idibaps),esther koplowitz center,roselló 149-153, Spain, institut d'investigacions biomèdiques august pi i sunyer (idibaps),esther koplowitz center,roselló 149-153,08036 barcelona,spain,centro de investigación biomédica en red de enfermedades hepáticas y digestivas, Spain
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Authors
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