The Pro12Ala Polymorphism of PPAR- γ gene is associated with sepsis disease severity and outcome in Chinese Han Population

Peroxisome proliferator-activated receptor-γ (ppar-γ) is a ligand-binding nuclear receptor,and its activation plays a prominent role in regulating the inflammatory response. therefore,ppar-γ has been suggested as a candidate gene for sepsis. in the present study,we investigated the association between the pro12ala polymorphism of ppar-γ and sepsis in a han chinese population. a total of 308 patients with sepsis and 345 healthy controls were enrolled in this study. genotyping was performed using the polymerase chain reaction-ligation detection reaction (pcr-ldr) method. no significant differences were detected in the allele and genotype distributions of the ppar-γ pro12ala snp between septic patients and controls (p = 0.622 for genotype; p = 0.629 for allele). however,stratification by subtypes (sepsis,septic shock,and severe sepsis) revealed a statistically significant difference in the frequency of the ala allele and ala-carrier genotype between the patients with the sepsis subtype and the healthy controls (p = 0.014 for allele and p = 0.012,for genotype). moreover,significant differences were found in the frequency of the ala allele and genotype between the sepsis survivors and nonsurvivors (all p = 0.002). in the survivors,the ppar-γ pro12ala genotype was significantly associated with decreased disease severity and recovery time (all p < 0.001). thus,genetic polymorphism is thought to play a role in the development and outcome of sepsis. © 2014 guoda ma et al.