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Peroxisome Proliferator-Activated Receptors in Female Reproduction and Fertility
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نویسنده
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vitti m. ,di emidio g. ,di carlo m. ,carta g. ,antonosante a. ,artini p.g. ,cimini a. ,tatone c. ,benedetti e.
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منبع
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ppar research - 2016 - دوره : 2016 - شماره : 0
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چکیده
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Reproductive functions may be altered by the exposure to a multitude of endogenous and exogenous agents,drug or environmental pollutants,which are known to affect gene transcription through the peroxisome proliferator-activated receptors (ppars) activation. ppars act as ligand activated transcription factors and regulate metabolic processes such as lipid and glucose metabolism,energy homeostasis,inflammation,and cell proliferation and differentiation. all ppars isotypes are expressed along the hypothalamic-pituitary-gonadal axis and are strictly involved in reproductive functions. since female fertility and energy metabolism are tightly interconnected,the research on female infertility points towards the exploration of potential ppars activating/antagonizing compounds,mainly belonging to the class of thiazolidinediones (tzds) and fibrates,as useful agents for the maintenance of metabolic homeostasis in women with ovarian dysfunctions. in the present review,we discuss the recent evidence about ppars expression in the hypothalamic-pituitary-gonadal axis and their involvement in female reproduction. finally,the therapeutic potential of their manipulation through several drugs is also discussed. � 2016 maurizio vitti et al.
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آدرس
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department of life health and environmental sciences,university of l'aquila,l'aquila, Italy, department of life health and environmental sciences,university of l'aquila,l'aquila, Italy, department of life health and environmental sciences,university of l'aquila,l'aquila, Italy, department of life health and environmental sciences,university of l'aquila,l'aquila,italy,gynecology and fertilityunit,san salvatore hospital,l'aquila, Italy, department of life health and environmental sciences,university of l'aquila,l'aquila, Italy, department of experimental,division of gynecology and obstetrics,university of pisa,pisa, Italy, department of life health and environmental sciences,university of l'aquila,l'aquila,italy,sbarro institute for cancer research,center for biotechnology,temple university,philadelphia,pa,united states,national institute for nuclear physics,gran sasso national laboratory,assergi, Italy, department of life health and environmental sciences,university of l'aquila,l'aquila,italy,gynecology and fertilityunit,san salvatore hospital,l'aquila, Italy, department of life health and environmental sciences,university of l'aquila,l'aquila, Italy
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Authors
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