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Peroxisome proliferator-activated receptor modulation during metabolic diseases and cancers: Master and minions
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نویسنده
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vitale s.g. ,laganà a.s. ,nigro a. ,la rosa v.l. ,rossetti p. ,rapisarda a.m.c. ,la vignera s. ,condorelli r.a. ,corrado f. ,buscema m. ,d'anna r.
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منبع
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ppar research - 2016 - دوره : 2016 - شماره : 0
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چکیده
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The prevalence of obesity and metabolic diseases (such as type 2 diabetes mellitus,dyslipidaemia,and cardiovascular diseases) has increased in the last decade,in both industrialized and developing countries. this also coincided with our observation of a similar increase in the prevalence of cancers. the aetiology of these diseases is very complex and involves genetic,nutritional,and environmental factors. much evidence indicates the central role undertaken by peroxisome proliferator-activated receptors (ppars) in the development of these disorders. due to the fact that their ligands could become crucial in future target-therapies,ppars have therefore become the focal point of much research. based on this evidence,this narrative review was written with the purpose of outlining the effects of ppars,their actions,and their prospective uses in metabolic diseases and cancers. © 2016 salvatore giovanni vitale et al.
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آدرس
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unit of gynecology and obstetrics,department of human pathology in adulthood and childhood,''g. barresi'' university of messina,messina, Italy, unit of gynecology and obstetrics,department of human pathology in adulthood and childhood,''g. barresi'' university of messina,messina, Italy, unit of diabetology and endocrino-metabolic diseases,hospital for emergency cannizzaro,catania, Italy, unit of psychodiagnostics and clinical psychology,university of catania,catania, Italy, unit of diabetology and endocrino-metabolic diseases,hospital for emergency cannizzaro,catania, Italy, department of general surgery and medical surgical specialties,university of catania,catania, Italy, department of clinical and experimental medicine,cramd (research centre of motor activity and metabolic rehabilitation in diabetes),university of catania,catania, Italy, department of clinical and experimental medicine,cramd (research centre of motor activity and metabolic rehabilitation in diabetes),university of catania,catania, Italy, unit of gynecology and obstetrics,department of human pathology in adulthood and childhood,''g. barresi'' university of messina,messina, Italy, unit of diabetology and endocrino-metabolic diseases,hospital for emergency cannizzaro,catania, Italy, unit of gynecology and obstetrics,department of human pathology in adulthood and childhood,''g. barresi'' university of messina,messina, Italy
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Authors
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