PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia

Peroxisome proliferator-activated receptor γ (ppar-γ) is a ligand-activated nuclear receptor that regulates the transcription of various genes. ppar-γ plays roles in lipid homeostasis,sebocyte maturation,and peroxisome biogenesis and has shown anti-inflammatory effects. ppar-γ is highly expressed in human sebaceous glands. disruption of ppar-γ is believed to be one of the mechanisms of primary cicatricial alopecia (pca) pathogenesis,causing pilosebaceous dysfunction leading to follicular inflammation. in this review article,we discuss the pathogenesis of pca with a focus on ppar-γ involvement in pathogenesis of lichen planopilaris (lpp),the most common lymphocytic form of pca. we also discuss clinical trials utilizing ppar-agonists in pca treatment. © 2017 sarawin harnchoowong and poonkiat suchonwanit.