Association of PPAR Alpha Intron 7 G/C,PPAR Gamma 2 Pro12Ala,and C161T Polymorphisms with Serum Fetuin-A Concentrations

Background. both peroxisome activator proteins (ppars) and fetuin-a play a role in lipid and glucose metabolism. aims. we investigated whether pparα intron 7 g2468/c and pparγ2 pro12ala and pparγ exon 6 c161t polymorphisms are associated with serum fetuin-a concentrations. patients and methods. the pparα intron 7 g/c polymorphism was studied in cohort 1 (79 reference individuals,165 postinfarction patients). the two pparγ polymorphisms were investigated in cohort 2 (162 reference individuals,165 postinfarction patients). fetuin-a levels and ppar polymorphisms were determined by radial immunodiffusion and polymerase chain reaction-restriction fragment length polymorphism techniques. results. the c allele variant of pparα intron 7 g2467c was associated with higher fetuin-a levels (p=0.018). postinfarction status (p=0.001),pparα intron 7 gg/gc/cc genotypes (p=0.032),and the c allele (p=0.021) were the strongest determinants of fetuin-a concentration in a multiple regression model. higher fetuin-a levels were associated with the pro variant of pparγ2 (p=0.047). postinfarction status (p=0.041) and bmi (p<0.001) but not pparγ2 pro were the strongest determinants of fetuin-a concentrations. pparγ exon 6 c161t genotypes were not associated with fetuin-a levels. conclusions. fetuin-a was determined mainly by the pparα intron 7c allele and postinfarction status in cohort 1 and the bmi and postinfarction in cohort 2. the pparα intron 7c and pparγ2 pro variants are associated with fetuin-a levels. © 2017 bernadett márkus et al.