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Subtle cardiovascular dysfunction in the unilateral 6-hydroxydopamine- lesioned rat
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نویسنده
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henderson j.m. ,slack k. ,billing r. ,matthews s. ,allbutt h.n. ,einstein r.
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منبع
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parkinson's disease - 2010 - شماره : 0
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چکیده
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The present study evaluated whether the unilateral 6-hydroxydopamine (6-ohda) model of parkinson's disease produces autonomic deficits. autonomic parameters were assessed by implanting a small radiofrequency telemetry device which measured heart rate variability (hrv),diurnal rhythms of heart rate (hr),core body temperature (cbt) and locomotor activity (la). rats then received 6-ohda lesion or sham surgery. 6-ohda lesioned rats exhibited head and body axis biases,defective sensorimotor function (disengage test),and prominent apomorphine rotation (all p <.05 versus controls). diurnal rhythm of hr was lower for 6-ohda lesioned rats (n = 8) versus controls (n = 6; p <.05). whilst hr decreased similarly in both groups during the day,there was a greater decrease in hr for the 6-ohda lesioned rats at night (by 38b.p.m. relative to 17b.p.m. for controls). la and cbt did not differ between surgery groups. this study indicates the unilateral 6-ohda model of pd shows subtle signs of cardiovascular autonomic dysfunction. copyright © 2010 k. slack et al.
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آدرس
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department of pharmacology,school of medical sciences,university of sydney,sydney, Australia, department of pharmacology,school of medical sciences,university of sydney,sydney, Australia, department of pharmacology,school of medical sciences,university of sydney,sydney, Australia, department of pharmacology,school of medical sciences,university of sydney,sydney, Australia, department of pharmacology,school of medical sciences,university of sydney,sydney, Australia, department of pharmacology,school of medical sciences,university of sydney,sydney, Australia
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Authors
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