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Temporal characteristics of high-frequency lower-limb oscillation during freezing of gait in Parkinson's disease
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نویسنده
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yungher d.a. ,morris t.r. ,dilda v. ,shine j.m. ,naismith s.l. ,lewis s.j.g. ,moore s.t.
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منبع
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parkinson's disease - 2014 - دوره : 2014 - شماره : 0
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چکیده
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A cardinal feature of freezing of gait (fog) is high frequency (3-8 hz) oscillation of the legs,and this study aimed to quantify the temporal pattern of lower-body motion prior to and during fog. acceleration data was obtained from sensors attached to the back,thighs,shanks,and feet in 14 parkinson's disease patients performing timed-up-and-go tasks,and clinical assessment of fog was performed by two experienced raters from video. a total of 23 isolated fog events,defined as occurring at least 5 s after gait initiation and with no preceding fog,were identified from the clinical ratings. the corresponding accelerometer records were analyzed within a 4 s window centered at the clinical onset of freezing. fog-related high-frequency oscillation (an increase in power in the 3-8 hz band >3 sd from baseline) followed a distal to proximal onset pattern,appearing at the feet,shanks,thighs,and then back over a period of 250 ms. peak power tended to decrease as the focus of oscillation moved from feet to back. there was a consistent delay (mean 872 ms) between the onset of high frequency oscillation at the feet and clinical onset of fog. we infer that fog is characterized by high frequency oscillation at the feet,which progresses proximally and is mechanically damped at the torso. © 2014 don a. yungher et al.
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آدرس
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human aerospace laboratory,department of neurology,mount sinai school of medicine,1 gustave l. levy place,new york, United States, human aerospace laboratory,department of neurology,mount sinai school of medicine,1 gustave l. levy place,new york, United States, human aerospace laboratory,department of neurology,mount sinai school of medicine,1 gustave l. levy place,new york, United States, parkinson's disease research clinic,brain and mind research institute,university of sydney,sydney, Australia, parkinson's disease research clinic,brain and mind research institute,university of sydney,sydney, Australia, parkinson's disease research clinic,brain and mind research institute,university of sydney,sydney, Australia, human aerospace laboratory,department of neurology,mount sinai school of medicine,1 gustave l. levy place,new york,ny 10029,united states,robert and john m. bendheim parkinson and movement disorders center,department of neurology,mount sinai school of medicine,new york, United States
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Authors
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