Addenbrooke's cognitive examination and individual domain cut-off scores for discriminating between different cognitive subtypes of Parkinson's disease

Objective. the main aim of this study was to verify the sensitivity and specificity of addenbrooke's cognitive examination-revised (ace-r) in discriminating between parkinson's disease (pd) with normal cognition (pd-nc) and pd with mild cognitive impairment (pd-mci) and between pd-mci and pd with dementia (pd-d). we also evaluated how ace-r correlates with neuropsychological cognitive tests in pd. methods. we examined three age-matched groups of pd patients diagnosed according to the movement disorder society task force criteria: pd-nc,pd-mci,and pd-d. roc analysis was used to establish specific cut-off scores of ace-r and its domains. correlation analyses were performed between ace-r and its subtests with relevant neuropsychological tests. results. statistically significant differences between groups were demonstrated in global ace-r scores and subscores,except in the language domain. ace-r cut-off score of 88.5 points discriminated best between pd-mci and pd-nc (sensitivity 0.68,specificity 0.91); ace-r of 82.5 points distinguished best between pd-mci and pd-d (sensitivity 0.70,specificity 0.73). the verbal fluency domain of ace-r demonstrated the best discrimination between pd-nc and pd-mci (cut-off score 11.5; sensitivity 0.70,specificity 0.73) while the orientation/attention subscore was best between pd-mci and pd-d (cut-off score 15.5; sensitivity 0.90,specificity 0.97). ace-r scores except for ace-r language correlated with specific cognitive tests of interest. © 2015 dagmar berankova et al.