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Personality Changes after Deep Brain Stimulation in Parkinson's Disease
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نویسنده
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pham u. ,solbakk a.-k. ,skogseid i.-m. ,toft m. ,pripp a.h. ,konglund a.e. ,andersson s. ,haraldsen i.r. ,aarsland d. ,dietrichs e. ,malt u.f.
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منبع
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parkinson's disease - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Objectives. deep brain stimulation of the subthalamic nucleus (stn-dbs) is a recognized therapy that improves motor symptoms in advanced parkinson's disease (pd). however,little is known about its impact on personality. to address this topic,we have assessed personality traits before and after stn-dbs in pd patients. methods. forty patients with advanced pd were assessed with the temperament and character inventory (tci): the urgency,premeditation,perseverance,sensation seeking impulsive behaviour scale (upps),and the neuroticism and lie subscales of the eysenck personality questionnaire (epq-n,epq-l) before surgery and after three months of stn-dbs. collateral information obtained from the upps was also reported. results. despite improvement in motor function and reduction in dopaminergic dosage patients reported lower score on the tci persistence and self-transcendence scales,after three months of stn-dbs,compared to baseline (p=0.006; p=0.024). relatives reported significantly increased scores on the upps lack of premeditation scale at follow-up (p=0.027). conclusion. stn-dbs in pd patients is associated with personality changes in the direction of increased impulsivity. © 2015 uyen pham et al.
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آدرس
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department of neuropsychiatry and psychosomatic medicine,oslo university hospital-rikshospitalet,oslo,norway,department of gerontopsychiatry,akershus university hospital,lørenskog,norway,institute of clinical medicine,university of oslo, Norway, department of neuropsychiatry and psychosomatic medicine,oslo university hospital-rikshospitalet,oslo,norway,department of neurosurgery,oslo university hospital-rikshospitalet, Norway, department of neurology,oslo university hospital-rikshospitalet, Norway, department of neurology,oslo university hospital-rikshospitalet, Norway, department of biostatistics and epidemiology,oslo university hospital-rikshospitalet, Norway, department of neurosurgery,oslo university hospital-rikshospitalet, Norway, department of neuropsychiatry and psychosomatic medicine,oslo university hospital-rikshospitalet,oslo,norway,department of psychology,university of oslo, Norway, department of neuropsychiatry and psychosomatic medicine,oslo university hospital-rikshospitalet, Norway, centre for age-related medicine,stavanger university hospital,stavanger,norway,department of neurobiology,care sciences and society,karolinska institute, Sweden, institute of clinical medicine,university of oslo,oslo,norway,department of neurology,oslo university hospital-rikshospitalet, Norway, department of neuropsychiatry and psychosomatic medicine,oslo university hospital-rikshospitalet,oslo,norway,institute of clinical medicine,university of oslo, Norway
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Authors
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