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Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population
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نویسنده
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lange j. ,lunde k.a. ,sletten c. ,møller s.g. ,tysnes o.-b. ,alves g. ,larsen j.p. ,maple-grødem j.
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منبع
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parkinson's disease - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Background. parkinson's disease (pd) and alzheimer's disease (ad) share pathological features,including amyloid-beta pathology. amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (app),and genetic variations in the processing pathway genes have been found to increase the risk of ad; however,the contribution in pd is unknown. methods. the aim of this study was to investigate whether candidate polymorphisms in five genes (adam10,bace1,bace2,psen2,and clu) involved in the app processing pathway affect pd risk in a population-based cohort of patients with incident pd and control subjects from the norwegian parkwest study. results. we found an association of rs638405 in bace1 with increased risk of pd,thus providing a novel link,at the genetic level,between amyloid-beta pathology and pd. © 2015 johannes lange et al.
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آدرس
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norwegian centre for movement disorders,stavanger university hospital, Norway, norwegian centre for movement disorders,stavanger university hospital,stavanger,norway,centre for organelle research,university of stavanger, Norway, centre for organelle research,university of stavanger, Norway, department of biological sciences,st. john's university,new york, United States, department of neurology,haukeland university hospital,bergen,norway,institute for clinical medicine,university of bergen, Norway, norwegian centre for movement disorders,stavanger university hospital,stavanger,norway,department of neurology,stavanger university hospital, Norway, norwegian centre for movement disorders,stavanger university hospital, Norway, norwegian centre for movement disorders,stavanger university hospital,stavanger,norway,centre for organelle research,university of stavanger, Norway
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Authors
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