The role of α-synuclein and LRRK2 in tau phosphorylation

There is now a considerable body of experimental evidence that parkinson's disease arises through physiological interaction of causative molecules,leading to tau pathology. in this review,we discuss the physiological role of α-synuclein and lrrk2 in the abnormal phosphorylation of tau. in addition,as recent reports have indicated that heat shock proteins-(hsps-) inducing drugs can help to ameliorate neurodegenerative diseases associated with tau pathology,we also discuss therapeutic strategies for pd focusing on inhibition of α-synuclein-and lrrk2-associated tau phosphorylation by hsps. © 2015 fumitaka kawakami and takafumi ichikawa.