Changing trend of uropathogens and antimicrobial sensitivity in complicated urinary tract infection in children

Background: the changing spectrum of micro-organisms causing urinary tract infection (uti) and emerging resistance to antimicrobials are upcoming problems around the globe. complicated uti develops in patients with immune deficiency and underlying renal defects (anatomical or functional). the causative organisms in complicated uti are usually resistant and difficult to treat resulting in frequent hospitalizations of patients. the aim of this study was to determine the culture and sensitivity pattern of complicated uti in pediatric population. material and methods: a descriptive cross-sectional observational study was performed utilizing prospective data in the department of nephrology at the children's hospital and the institute of child health lahore pakistan. a total of 49 patients with complicated uti were selected from july to december 2014. results: amongst the 49 patients selected with complicated uti,69.4% (n= 34) were males and 30.4% (n= 15) were females. the most common causative organism was klebsiella (40.0%) followed by e.coli (26.0%) and peudomonas (16.0%). these organisms showed the highest sensitivity to meropenem,piperacillin+tazobactam,amikacin and fosfomycin,while resistance was observed for third-generation cephalosporins and ciprofloxacin. conclusion: klebsiella is the leading organism in complicated uti and there is high rate of resistance to commonly used antimicrobials. © 2016,pakistan pediatric journal. all rights reserved.