G6PD deficiency in neonates with jaundice

Background: glucose-6-phosphate dehydrogenase deficiency is an xlinked recessive disorder,prevalent in 400 million individuals worldwide. it constitutes a common inherited cause of neonatal jaundice. objectives: to determine the frequency of glucose-6-phosphate dehydrog place and duration: neonatal intensive care unit,national institute of child health,karachi from 18th december 2013 to 17th june 2014. study design: cross sectional study patients & methods: all neonates with serum indirect bilirubin of >05 mg/dl were hospitalized and included in the study. bio data,detail history and physical examination was performed. blood sample for g6pd levels were sent to the laboratory. g6pd level of < 6.97 iu/ghb was considered as deficient & level ≥ 6.97 iu/ghb was considered as normal. data was analysed using spss version 20.p value of < 0.05 was considered significant. results: a total of 131 neonates with jaundice were included in the study males were 78 (59.54%) and females were 53 (40.46%) with a ratio of 1.47:1. the age of patients ranged from 1 to 28 days with a mean age of 8.89 ± 5.34 days. mean ± sd of bilirubin is 9.9 ± 3.2mg/dl. g6pd level was deficient in 13 (9.92%) jaundiced neonates while 118 (90.08%) jaundiced neonates had a normal level of g6pd enzyme. among them 9 (69.23 %) were male and 4 (30.77%) were female. conclusion: g6pd deficiency is a common inherited cause of neonatal jaundice. it was seen in 9.9% of jaundiced neonates. © 2016,pakistan pediatric journal. all rights reserved.