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A systematic approach to develop level a,in-vitro and in-vivo correlation (IVIVC)-ketoprofen bcs class II drug example
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نویسنده
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sarfraz m. ,ahmad m. ,sarfraz a.
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منبع
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pakistan journal of scientific and industrial research series b: biological sciences - 2012 - دوره : 55 - شماره : 1 - صفحه:15 -26
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چکیده
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Three modified releases; slow release (sr),moderate release (mr) and fast release (fr) matrix tablets of ketoprofen,bcs class ii drug,were manufactured by wet granulation method. the similarity factor (f2) was used to analyze dissolution data. randomized,three way,crossover bioavailability study of 12 h was conducted on nine (9) healthy volunteers. the in-vitro release profile of ketoprofen in phosphate buffer ph 7.5 with sls (sodium lauryl sulphate 1%) at 100 rpm was found most fit to develop level a ivtvc. a linear correlation (r2 & 0.9) was found in level a,c and multiple c but a non-linear relationship was observed in level b.
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کلیدواژه
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Correlation; IVTVC; Ketoprofen; Matrix System; Similarity factor
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آدرس
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facuity of pharmacy and alternative medicine,islamia university of bahawalpur,bahawalpur,pakistan,pharmacy department,university of lahore, Pakistan, facuity of pharmacy and alternative medicine,islamia university of bahawalpur, Pakistan, facuity of pharmacy and alternative medicine,islamia university of bahawalpur,bahawalpur,pakistan,pharmacy department,university of lahore, Pakistan
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Authors
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