Comparative efficacy of some quinolones and doxycycline against chronic infection of Brucella melitensis 16M in BALB/c mice

This study was under taken to observe various treatment methods for brucellosis caused by brucella melitensis. the effect of therapeutic regimens with ciprofloxacin,ofloxacin and levofloxacin alone or in combination with doxycycline was assessed against b. melitensis chronic infection using 200 mice. doxycycline alone or in combination with ciprofloxacin was significantly found to reduce the infection till 135 days post-infection (p<0.0001). moreover,doxycycline was more effective than ciprofloxacin and ofloxacin 135 days post-infection (p = 0.04 and p = 0.02,respectively). however,treatment with quinolone-doxycycline combinations revealed synergistic effects as they were able to reduce the splenic cell forming unit (cfu) from day 45 post-infection. similarly,doxycycline treatment reduced the splenic colony forming unit (cfu) from day 90 post-infection. in conclusion,doxycycline seems to be the most effective agent against brucella chronic infection. © 2016,pcsir-scientific information centre. all rights reserved.