Correlation of platelet aggregation with serum lipids level in women taking hormonal contraception

Increased platelet functional activity has been noticed as an initial disorder in women taking hormonal contraception leading to hypercoaguable state in these subjects. this is due to direct effect of estrogen present in oral contraceptive pills on platelet functional activity while progesterone,by changing plasma lipids level has indirect role in the genesis of thromboembolism. present study was conducted in women taking oral pills (group b) and injectable contraceptive preparations (group c) and their results were compared with control (group a). platelet hyperaggregation was determined by using adp and collagen as agonist. serum lipids levels were also measured. a positive correlation between platelet hyperactivity and raised lipids level had been observed. statistically,p value (< 0.01) was significant in group b and group c as compared to group a.