Thrombocytopenia during pregnancy at LUMHS,Hyderabad,Sind

Objective: to study the relationship between thrombocytopenia in pregnancy associated with various causes. place and duration of study: the departments of pathology and obstetrics & gynaecology,liaquat university of medical and health sciences,hyderabad,jamshoro from march 2011 to august 2011. methods: 1130 consecutive pregnant women were admitted during 6-month period. results: incidence of thrombocytopenia in pregnancy was 13.11% (145/1130). the main causes of thrombocytopenia in pregnancy were gestational thrombocytopenia (gt) (55.5%),preeclampsia (21.2%),immune thrombocytopenic purpura (itp) (16.8%),hellp (hemolysis,elevated liver enzymes and low platelet count) syndrome (13.45%) and hcv positive pregnant women were (8.02%). women with thrombocytopenia were significantly older compared with patients without thrombocytopenia,and had higher rates of labor induction (or=5.0,95% ci=2.2-7.6,p<0.001) and preterm deliveries (or=3.5,95% ci=1.9-6.5,p<0.001). thrombocytopenia was significantly associated with preterm delivery. higher rates of placental abruption and pph were found in pregnant women with thrombocytopenia (or=90.2,95% ci=1.5-33.2,p=0.001). conclusions: thrombocytopenia in pregnancy was associated with maternal and perinatal morbidity with the strongest association with preeclampsia,hcv positivity and hellp syndrome. the lower the platelet count,the higher the risks for the fetus/new-born.