Impact of pregnancy on c-peptide levels of type-II diabetic women

Objectives: the present study proposes to observe the changes in serum c-peptide levels,hba1c and fasting blood sugar (fbs) levels in pregnant and non-pregnant diabetes mellitus type ιι (d.m) patients and compare these changes. method: thirty pregnant women with d.m type ιι were selected for the study. the subjects were evaluated for pregnancy status and presence of d.m and then fbs,hba1c and serum c-peptide levels were assessed. results: results showed significantly decreased (p< 0.001) levels of fbs and hba1c in pregnant group as compared to non-pregnant group where as serum c-peptide levels were significantly increased (p<0.001) in pregnant group when compared to non-pregnant diabetic group. conclusion: it is concluded that fbs and hba1c levels were lowered in pregnant diabetics as compared with non-pregnant diabetics. this lowering is accompanied with increased levels of circulating c-peptide of insulin,suggesting a state of hyperinsulinemia.