Comparison of two diagnostic methods for detection of H pylori i.e.,gastric biopsy by H&E & giemsa and serum anti H pylori antibodies

Objective: to study and compare two different techniques for diagnosis of h.pylori i.e.,endoscopic biopsy,and antibody detection. study of design: institution based prospective comparative study place & duration of study: the department of pathology & medicine and surgery liaqat university of medical and health sciences,jamshoro from oct. 2009 to feb 2011. methods: 100 patients of all age groups and both sexes with complaint of dyspepsia,or having the clinical suspicion of h. pylori associated gastritis were included in the study with gastric biopsies and serum samples. results: out of 100 gastric biopsy cases,h. pylori were seen in 90 (90%) cases. amongst which 52(57.7%) were male and 38(42.3%) were female,and on serum analysis elisa technique,h. pylori antibodies were in 68(68%) cases,amongst which 38(55.9) were male and 30(44.1%) were female. the sensitivity of this technique was seen 75.55% and specificity 60%. conclusion; h. pylori positivity is highly significant in histological examination and the detection of anti-h. pylori antibodies from serum by elisa method is simplest and least expensive.