Evaluation of frequency and clinico-hematological features of acute myeloid leukemia at a Tertiary Care Hospital,Lahore

Objective: to evaluate the frequency and clinic hematological features of aml. study design: cross sectional observational prospective study of 5 year duration. patients and methods: newly diagnosed cases of aml of all age groups and both genders were included in the study. the exclusion criteria included patients who were already diagnosed,were on chemotherapy or radiotherapy of aml. a detailed history including age of presentation of the disease and general and physical examination were obtained. history of exposure to drugs,chemicals and occupational history were noted. laboratory analysis included complete blood counts and bone marrow examination. results: in 82 patients of acute leukemia,frequency of all was 47(57.3%) and aml was 35(42.7%). out of 35 aml patients,21(60%) were male and 7(40%) were female. of these 35 patients,24(68.6%) were adults (>15 years of age) and 11(31.4%) were children (<15 years of age). regarding subtypes of aml,m3 was most common of all and its frequency was estimated to be about 13(37%) followed in order by m 2 which was10 (29%),m1 was 7(20%),m4 was 3(8%) and m6 was 2(6%). the most common presenting complaints were pallor,fever and bleeding. the constitutional signs were splenomegaly,hepatomegaly,lymphadenopathy,gum hypertrophy,petechiae and bruises. infiltration of soft tissues by leukemic cells was common in aml-m3 and m1. conclusion: acute myeloid leukemia is more common in adults with a male preponderance. its clinical manifestations are variable in its different subtypes.