Variations of multiple sclerosis lesions on MRI and their cognitive effect

Objective: early detection of demyelinating brain plaques and variations in appearance on mri and impact on cognitive effect. study design: a retrospective study of 25 patients. settings: this study was conducted in radiology department of mayo hospital. patient referred from different mri centers. duration of study: it was completed in 3 months from october to december 2012. subjects and methods: first 25 consecutive patients referred for mri brain and spinal cord reporting were retrospectively evaluated for detail characterization of lesions with their cognitive effect of demyelinating diseases particularly multiple sclerosis. results: 15 patient having white matter periventricular ovoid lesions. in acute phase mostly are enhancing. in 5 pateints lesions preset in the spinalcord along brain parnchyma. 3 of them showing temporal lobe lesions. rest of the two patient present with atypical features. conclusion: demyelinating brain and spinal cord disease showing variable pattern,involving brain white matter and spinal cord. in acute phase lesions are enhancing. there cognitive effect are according to the site of involvement.