Effect of raloxifene on T score of Bones in post menopausal women

Aim: to study the effect of 60 mg/day raloxifene on bone mineral density in post menopausal women in one year. study design: a case control study conducted among 30 cases at defence hospital and surgimed hospital,lahore from 2011 to 2012. inclusion criteria: age > 50 years,taking 60mg/day raloxifene >1 year,menopause > 1 year exclusion criteria: age < 50 years,bone pathologies,drug intake,endocrine pathologies methods: the patients were divided in two groups; group 1 taking raloxifene 60 mg/day for > 1 year,group 2 not taking raloxifene. all patients were given a questionnaire about age,parity,history of pain & fractures,height shortening,awareness about preventive measures. then t score of calcaneum bone of both groups measured in opd by machine. in both the groups value of t score,questionnaire and various bone problems like pain,fracture,height shortening was noted and evaluated statistically,p < 0.05 was significant. results: there were significantly different results in group 1 and 2. in group 1,t scores were better about above 1.5 (p=0.00),less fractures (n=4) 4% (p=0.003) and no height shortening (n=0) p=0.001 as compared to group 2,whereas pain (n=20) 67% p=0.266 in group 1 and in group 2 (n=22) 76% not significant in both groups. conclusion: raloxifene 60 mg/day significantly increases bone mineral density after 12 months of therapy.