To study the Co-relation of endometrial thickness and endometrial biopsy in a group of Peri and post menopausal women

Aims: to find out the co-relation of endometrial thickness & endometrial biopsy in a group of peri and post menopausal women. study design: comparative study duration of study: 8-11 months. methods: endometrial thickness was measured in 50 women aged 39 to 65 years who later underwent endometrial biopsy. women undergoing estrogen replacement were excluded from study. diagnosis can be made by excluding intrauterine pathology like submucosal myomas using transvaginal sonogram. women who reported 8 or more days of bleeding were included in the study. they were divided into two groups based on menstrual status i.e. peri and post menopausal status. a sonographic recommended pattern was ecountered in the study. results: endometrial biopsy showed that benign endometrial polyp,cystic glandular hyperplasia and adenomatous hyperplasia with atypia had average endometrial thickness of 17.25,16.00 and 23.33 mm respectively. this sonographic pattern is more common in peri menopausal women. on the other hand mid to late secretary phase with endometrial thickness of 7.39mm were common in both pre and perimenopausal group. endometrial biopsy in post menopausal women showed that this group of women was more susceptible to cystic glandular hyperplasia and moderate to well differentiate papillary carcinoma having an endometrial thickness of 16.0 and 18.60 mm respectively. on the other hand,both peri and post menopausal women are at high risk of developing endometrial adenocarcinoma (endometrial thickness,29.33mm). conclusion: women with perimenopausal status are at greater risk of developing endometrial cancer as compared to post menopausal women. in a postmenopausal woman if the endometrium measures > 4 mm in thickness a biopsy should be considered as the risk of cancer is 10.1%,whereas if the endometrium measures