Study of effect of pesticides on total bilirubin and direct bilirubin levels in blood of workers of pesticide formulation & packing plants in Pakistan: Multiplexing with ALP,ALT and AST

Aim: to evaluate the impact of pesticides on t bilirubin and d bilirubin,alp,alt and ast among workers of pesticide formulation & packing plants in pakistan methods: one hundred workers in the age group of 20-50 years working at different pesticide formulation and packing units for at least one year were included in this study. one hundred healthy workers with no history of exposure to pesticides with matching age,sex and social status were taken as control. biochemical tests t bilirubin and d bilirubin were carried out employing chemistry autoanalyzer,dimension rxl (dade behring),results: in current study,mean t bilirubin value for 100 control subjects was 0.51 mg/dl. regarding 100 pesticide industrial workers mean t bilirubin value was 0.68 mg/dl. on the other hand serum of 100 control subjects indicated mean d bilirubin value of 0.20 mg/dl. regarding mean d bilirubin value for 100 pesticide industrial workers was 0.24 mg/dl. these results revealed that all the hundred pesticide industrial workers had normal t bilirubin and d bilirubin levls but on the higher side as compared to control subjects. p value was significant. conclusion: all pesticide industrial workers had normal t bilirubin and d bilirubin levels but on the higher side as compared to control subjects. future studies must converge on a deeper analysis of the oxidative stress induced misrepresentation of protein network at cellular level.