Efficacy of letrozole as first line ovulation induction agent in subfertile women

Aim: to determine the efficacy of letrozole,an aromatase inhibitor as a first line ovulation induction agent in subfertile women methods: this prospective study was conducted among 120 subfertile women. letrozole was given as 2.5 mg twice daily dose from day 3 to day 7 of menstrual cycle. follicular growth was monitored on ultrasound. fertile period explained to couple. hcg given on follicular growth of 19-22mm. pregnancy was confirmed by urine test when cycle became overdue and later confirmed by ultrasound. results: out of 120 patients follicular growth occurred in 108 patients (90%),pregnancy occurred in 48 patients (40%). three patients had miscarriage (2.5%) per cycle pregnancy rate. none had hyperstimulation syndrome or multiple gestation. conclusion: letrozole may be considered as safe and effective first line drug for ovulation induction with minimal side effects.