Role of IMA in acute chest pain in relation with troponin-I and total lipids for early diagnosis of MI in acute coronary syndrome (ACS)

Aim: to evaluate the role of ischemia modified albumin (ima) in serum in relation with cardiac troponin-i and total lipid profile in patients with chest pain for early diagnosis of myocardial ischemia prone to myocardial infarction in acute coronary artery syndrome subjects. methods: present study was carried out in the department of biochemistry,bmsi,jpmc,in collaboration with national institute of cardiovascular diseases (nicvd) karachi. 228 patients out of 1050 were randomly selected who have continuously chest pain for three hours and were divided in three groups. in group-a patients having chest pain continuously for three hours with normal ecg and troponin-i,group-b patients with chest pain have developed ecg changes within three hours,group-c patients with chest pain followed by mi with increased troponin-i. results: positive significant good correlation (p < 0.01) among ima and ctn-i in patients admitting in emergency ward with chest pain within three hours (group-a) favour in differentiation of angina from muscular pain. while patients with chest pain & developed ecg changes (group-b) showed that ctn-i,cholesterol,triglyceride,hdl-c and ldl-c when correlated with ima showed some what significant positive correlation (p < 0.01) versus ima while ima,cholesterol,triglyceride,hdl-c and ldl-c when correlated with ctn-i,showed statically significant positive correlation (p < 0.01) versus ctn-i. conclusion: serum ima level should be routinely performed at the time when patient attending the emergency department in combination with measurement of cardiac troponin-i and ecg,to confirm or exclude a final diagnosis of ischemic heart disease and to exclude myocardial infarction.